The neural basis of interoception across psychiatric disorders

This paper meta-analysed transdiagnostic differences in neural activation during interoception. Left dorsal mid-insula activation was a common disruption in patients with a range of disorders, during interoceptive probes assessing pain, hunger, and interoceptive attention. This activation was anatomically distinct from brain regions involved in affective processing and from regions altered by psychological or pharmacological interventions […]

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Trauma-focused Cognitive Therapy for acute PTSD in children

This paper presents the results of a randomised controlled trial providing preliminary support for Trauma-focused Cognitive Therapy for acute PTSD in children and adolescents delivered in the early (3-6 months) post-trauma phase. MEISER-STEDMAN, R., Smith, P., MCKINNON, A., DIXON, C., Trickey, D., Ehlers, A., Clark, D.M., Boyle, A., WATSON, P., Goodyer, I. & DALGLEISH, T. […]

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The Memory Flexibility (MemFlex) intervention for depression

In a series of randomised controlled trials, we have explored the efficacy of Memory Flexibility Training – MemFlex – for clinical depression. The first trial showed promising efficacy relative to an active counselling control. Free access to the paper at https://www.sciencedirect.com/science/article/pii/S0005796718301359 We then ran a subsequent trial which showed that MemFlex did not decrease the risk […]

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Improving identification of very young children with PTSD

This paper reports the first population-representative epidemiological studies of the prevalence of PTSD in very young children. The results showed that using a developmentally-appropriate PTSD algorithm resulted in up to 20-fold increases in the estimate for PTSD prevalence in children under 6 years old. HITCHCOCK, C., GOODALL, B., Sharples, Meiser-Stedman, R., WATSON, P., Ford T. […]

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Helping to reduce depressive relapse

C2AD researchers (names in caps below) contributed to an individual patient data mega-analysis across all published Mindfulness Based Cognitive Therapy (MBCT) trials. The paper shows that MBCT is superior both to usual care and to anti-depressant medication as a secondary prevention for depressive relapse in those with a history of recurrent depression. It contributed to […]

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June C2:AD Seminar – Be careful what you wish for: Personal goals and psychological distress.

Nick Moberly (Mood Disorders Centre, University of Exeter). Be careful what you wish for: Personal goals and psychological distress. Personal goal pursuits provide structure and meaning to life and contribute to affective and cognitive experience. Control theory (‘cybernetic’) accounts suggest that negative affect and rumination signal that rates of progress on important goals are unsatisfactory. […]

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CLIMB – the Mental Health Data Pathfinder has launched!

The CLIMB Project is a Mental Health Data Pathfinder grant funded by the Medical Research Council. Seven research teams are collaborating to bring together psychiatrists, clinical data experts, computational biologists and teams with expertise in cognitive neuroscience, experimental medicine and immunopsychiatry. The project combines the expertise of the University of Cambridge and Cambridge and Peterborough […]

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C2:AD April Seminar

For the April C2:AD seminar, we will be hosting:  Gary Brown ( Royal Holloway). Measurement in psychotherapy outcome and process research: Old obstacles and new developments.  The central challenge of clinical research is to translate findings from study samples that aggregate across individuals to the idiosyncratic needs of those seeking services. This depends critically on (1) […]

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LIVE C2:AD Workshop – New developments: Cognitive-behavioural therapies for OCD, Dr Jan van Niekerk.

C2:AD Workshop – New developments: Cognitive-behavioural therapies for OCD. Dr Jan van Niekerk. Most clinicians are familiar with exposure and response prevention treatment and cognitive appraisal model CBT for OCD. However, many are not familiar with newer models such as inference-based therapy, metacognitive therapy and ACT.  The workshop will aim to clarify OCD DSM-5 diagnosis, […]

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