PREVENT
A core aim of the centre is to develop and evaluate preventative interventions for affective disorders in children and adults.
PREVENT was a large (N=420) definitive RCT based at the University of Exeter, in collaboration with C2:AD, that evaluated Mindfulness Based Cognitive Therapy (MBCT), in comparison to continuation anti-depressant medication in the prevention of depressive relapse over a two year period. Read more here.
PREVENT showed that MBCT was comparable to maintenance anti-depressant medication for the prevention of depression recurrence in individuals with at least three previous episodes. The results informed the inclusion of MBCT in NICE guidance.
The main findings are presented in the following papers:
MYRIAD
The MYRIAD (MY Resilience In ADolescence) Project asked how we can best support the mental health of young people aged 11-16. We wanted to see if mindfulness training could be effective in adolescents. Specifically, we wanted to ask if schools-based mindfulness training is an effective, cost-effective, accessible and scale-able way to promote mental health and well-being in adolescence. The MYRIAD Project involved more than 28,000 children, 650 teachers, 100 schools and 20 million data points. MYRIAD showed that mindfulness-based intervention was no better than usual teaching provision in preventing mental health problems in young people.
The full list of the outputs from the wider MYRIAD project can be found here.
The main initial publications for MYRIAD that were part of a special issue of BMJ: Mental Health:
Axford, N., Berry, V., Lloyd, J., & Wyatt, K. (2022). How can we optimise learning from trials in child and adolescent mental health?. BMJ Evidence-Based Mental Health. Doi: 10.1136/ebmental-2022-300500
Kuyken, W., Ball, S., Crane, C., Ganguli, P., Jones, B., Montero-Marin, J., Nuthall, E., Raja, A., Taylor, L., Tudor, K., Viner, R.M., Allwood, M., Aukland, L., Dunning, D., Casey, T., Dalrymple, N., De Wilde, K., Farley, E.R., Harper, J., Kappelmann, N., Kempnich, M., Lord, L., Medlicott, E., Palmer, L., Petit, A., Philips, A., Pryor-Nitsch, I., Radley, L., Sonley, A., Shackleford, J., Tickell, A., MYRIAD team, Blakemore, S.J.*, Ukoumunne, O.C.*, Greenberg, M.T.*, Ford, T.*, Dalgleish, T.*, Byford, S.*, & Williams, JMG*. (2022). Effectiveness and cost-effectiveness of universal school-based mindfulness training compared with normal school provision in reducing risk of mental health problems and promoting well-being in adolescence: the MYRIAD cluster randomised controlled trial. BMJ Evidence-Based Mental Health. Doi: 10.1136/ebmental-2021-300396
*Joint senior authors
Kuyken, W., Ball, S., Crane, C., Ganguli, P., Jones, B., Montero-Marin, J., Nuthall, E., Raja, A., Taylor, L., Tudor, K., Viner, R.M., Allwood, M., Aukland, L., Dunning, D., Casey, T., Dalrymple, N., De Wilde, K., Farley, E.R., Haper, J, Hinze, V., Kappelmann, N., Kempnich, M., Lord, L., Medlicott, E., Palmer, L., Petit, A., Philips, A., Pryor-Nitsch, I., Radley, L., Sonley, A., Shackleford, J., Tickell, A., MYRIAD team, Blakemore, S.J.*, Ukoumunne, O.C.*, Greenberg, M.T.*, Ford, T.*, Dalgleish, T.*, Byford, S.*, & Williams, J.M.G*. (2022). Effectiveness of universal school-based mindfulness training compared with normal school provision on teacher mental health and school climate: results of the MYRIAD cluster randomised controlled trial. BMJ Evidence-Based Mental Health. Doi: 10.1136/ebmental-2022-300424
*Joint senior authors
Montero-Marin, J., Allwood, M., Ball, S., Crane, C., De Wilde, K., Hinze, V., Jones, B., Lord, L., Nuthall, E., Raja, A., Taylor, L., Tudor, K., MYRIAD team, Blakemore, S.J.*, Byford, S.*, Dalgleish, T.*, Ford, T.*, Greenberg, M.*, Ukoumunne., O.C.*, Williams, J.M.G.*, & Kuyken, W.* (2022). School-based mindfulness training in early adolescence: what works for whom, and how in the MYRIAD trial?. BMJ Evidence-Based Mental Health. Doi: 10.1136/ebmental-2022-300439
*Joint senior authors
Dunning, D., Ahmed, S., Foulkes, L., Griffin, C., Griffiths, K., Leung, J.T., Parker, J., Piera Pi-Sunyer, B., Sakhardande, A., Bennett, M., Haag, C., Montero-Marin, J., Packman, D., Vainre, M., Watson, P., MYRIAD team, Kuyken, W*., Williams, J.M.G*, Ukoumunne, O.C.*, Blakemore, S.J.*, & Dalgleish, T.* (2022). The impact of mindfulness training in early adolescence on affective executive control, and on later mental health during the COVID-19 pandemic: A randomised controlled trial. BMJ Evidence-Based Mental Health. Doi: 10.1136/ebmental-2022-300460
*Joint senior authors
Dunning, D., Tudor, K., Radley, L., Dalrymple, N., Vainre, M., Ford, T.*, Montero-Marin, J.*, Kuyken, W*., & Dalgleish, T*. (2022). Do mindfulness-based programmes improve the cognitive skills, behaviour and mental health of children and adolescents? An updated meta-analysis of randomised controlled trials. BMJ Evidence-Based Mental Health. Doi: 10.1136/ebmental-2022-300464
*Joint senior authors
Cuijpers, P. (2022). Universal prevention of depression at schools: dead end of challenging crossroad? [Editorial]. BMJ Evidence-Based Mental Health Editorial. Doi: 10.1136/ebmental-2022-300469
DECADES
Following on from the main MYRIAD schools-based trial, through a process of reverse translation we distilled a core ingredient of the schools-based mindfulness programme – psychological decentering – and compiled a novel low intensity intervention for at risk adolescents. The publications for this latest part of the MYRIAD study to date are here:
SWELL
Our trial investigating the utility of mindfulness-based interventions to improve productivity in the workplace is here: