Welcome to the Cambridge Clinical Research Centre in Affective Disorders
The Cambridge Clinical Research Centre in Affective Disorders (C2:AD) was established in 2009 to support research that improves understanding and treatment of affective disorders such as depression, anxiety, and post-traumatic stress reactions.
The research emphasis is on the development and evaluation of clinical interventions for affective disorders that have a strong translational grounding in basic mind and brain sciences.
C2:AD is a partnership between the Medical Research Council Cognition and Brain Sciences Unit (MRC CBSU), Cambridgeshire and Peterborough NHS Foundation Trust (CPFT) and the University of Cambridge, created to foster collaboration and synergy between NHS clinical practitioners and clinical researchers from academic departments, with input from service-users and carers.
Latest news
- 25 June 2025 Tim Dalgleish and Anna Bevan are giving a half-day workshop on Transdiagnostic approaches to mental health and psychological therapy
- The PYCES-II trial – “A randomised controlled efficacy trial of trauma-focused cognitive behaviour therapy for posttraumatic stress disorder (PTSD) in young children aged 3-8 years” funded by NIHR, hosted by C2:AD and sponsored by CPFT has now started!
- The NIHR has awarded £500K of funding for our project “Psychological decentering for the prevention of depression and the promotion of wellbeing in adolescents: A randomised controlled efficacy trial”
- Tim Dalgleish gave a keynote address at the Australian Association for Cognitive and Behaviour Therapy Annual Conference, Brisbane. “Fragile minds in a scary world: post-traumatic stress in children and young people from preschool to adolescence”
- Tim Dalgleish gave the The Alice Barber Lecture at the University of Melbourne. “From mindfulness to decentering: In search of contemplative parsimony”
- NIHR awards £775K to CPFT to set up “The Cambridge and East of England Complex Depression Research Clinic” from October 2025, supported by C2:AD.
- Georgina Clifford and Tim Dalgleish presented a 1-day workshop: “Working as a Psychologist Expert Witness specialising in Trauma and Memory: From Instruction to Cross Examination”
- The NIHR has awarded £500,000 funding for the PYCES-II trial: “A randomised controlled efficacy trial of trauma-focused cognitive behaviour therapy for posttraumatic stress disorder (PTSD) in young children aged 3-8 years”.
- Tim Dalgleish gave the Invited keynote address. “There’s no point crying over spilt milk … or is there? Why we have emotions and why we couldn’t manage without them.” at the BNA Festive Symposium
- Cambridge are part of the newly funded UKRI Mental Health Platform Hubs : “Complex Emotions” (led by Scott Weich in Sheffield. Tim Dalgleish: Co-Applicant); and “ImmunoMind” led by Ed Bullmore, Cambridge.
