This paper meta-analysed transdiagnostic differences in neural activation during interoception. Left dorsal mid-insula activation was a common disruption in patients with a range of disorders, during interoceptive probes assessing pain, hunger, and interoceptive attention. This activation was anatomically distinct from brain regions involved in affective processing and from regions altered by psychological or pharmacological interventions for affective disorders. Dorsal mid-insula activation may represent a neural marker of mental health disorders.
NORD C.L., Lawson R.P., & DALGLEISH T. (2021) Disrupted dorsal mid-insula activation during interoception across psychiatric disorders. American Journal of Psychiatry, in press.
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